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HIV inhibitor

" in MedChemExpress (MCE) Product Catalog:

By Targets:	HIV (448) HIV Integrase (38) HIV Protease (71) Akt (2) Amino Acid Derivatives (1) Antibiotic (9) Apelin Receptor (APJ) (8) Apoptosis (45) Autophagy (29) Bacterial (11) Bcl-2 Family (1) Calcium Channel (1) Caspase (1) CCR (10) CDK (4) Cholinesterase (ChE) (1) CMV (2) CRISPR/Cas9 (3) CRM1 (2) CXCR (16) Cytochrome P450 (11) Dengue virus (4) DGK (1) DNA/RNA Synthesis (16) Drug Metabolite (6) Dynamin (1) EBV (1) Endogenous Metabolite (36) Epigenetic Reader Domain (3) ERK (1) FAK (1) Flavivirus (4) Fungal (3) Glucosidase (1) GLUT (1) GSK-3 (1) HBV (20) HCV (7) HDAC (9) HMG-CoA Reductase (HMGCR) (1) HPV (1) HSV (6) IKK (2) Influenza Virus (6) Integrin (1) Interleukin Related (1) Isotope-Labeled Compounds (41) JNK (1) LIM Kinase (LIMK) (1) Microtubule/Tubulin (1) Mitochondrial Metabolism (5) Mitophagy (5) MMP (4) NF-κB (7) NOD-like Receptor (NLR) (4) Notch (3) Nucleoside Antimetabolite/Analog (14) Organoid (2) Oxidative Phosphorylation (1) P-glycoprotein (6) P2X Receptor (1) Parasite (14) Phosphatase (1) PKC (2) Proteasome (2) Proton Pump (1) RABV (1) Reactive Oxygen Species (5) Renin (1) Reverse Transcriptase (90) SARS-CoV (26) SGLT (1) Sodium Channel (1) Src (3) STAT (1) Telomerase (4) Toll-like Receptor (TLR) (2) Topoisomerase (2) Tyrosinase (1) Virus Protease (1) VSV (1) Wnt (1) Xanthine Oxidase (1) YB-1 (1)
By Research Areas:	Cancer (110) Cardiovascular Disease (7) Endocrinology (15) Infection (479) Inflammation/Immunology (66) Metabolic Disease (13) Neurological Disease (7)
Click Chemistry:	Azide (13) Alkynes (8)

539

Inhibitors & Agonists

Screening Libraries

Fluorescent Dye

Peptides

Inhibitory Antibodies

Natural
Products

Isotope-Labeled Compounds

Click Chemistry

Targets Recommended: HIV HIV Integrase HIV Protease

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-149350

HIV-1 inhibitor-57	HIV	Infection
HIV-1 inhibitor-57 (Compound 12g) is a *HIV* inhibitor. HIV-1 inhibitor-57 is active against wild-type and five prevalent NNRTI-resistant HIV-1 strains with EC₅₀ values ranging from 0.024 to 0.0010 μM. HIV-1 inhibitor-57 forms additional interactions with residues around the binding site in HIV-1 RT .

HY-163177

HIV-1 inhibitor-63	HIV	Infection
HIV-1 inhibitor-63 (compound S17) is a potent *HIV-1* inhibitor. HIV-1 inhibitor-63 inhibits integrase-Ku70 complex formation with an IC₅₀ value of 12 µM. HIV-1 inhibitor-63 inhibits HIV-1 post-integration DNA repair .

HY-152539

HIV-1 inhibitor-54	HIV	Infection
HIV-1 inhibitor-54 is a potent *HIV-1* inhibitor. HIV-1 inhibitor-54 has anti-HIV activity in MT-4 cells against WT HIV-1 (strain IIIB) with an EC₅₀ value of 0.032 μM. HIV-1 inhibitor-54 can be used for the research of virus infection .

HY-163362

HIV-1 inhibitor-65	Reverse Transcriptase PKC HIV	Infection
HIV-1 inhibitor-65 (compound 3c) is an inhibitor of HIV-1 (EC₅₀: 2.9 nM) and an activator of protein kinase C (PKC). HIV-1 inhibitor-65 inhibits syncytium formation (EC₅₀: 7.0 nM) and inhibits HIV-1 entry and HIV-1 reverse transcriptase .

HY-146089

HIV-1 inhibitor-32	HIV	Infection
HIV-1 inhibitor-32 (compound 3c) is a potent *HIV-1* inhibitor with an IC₅₀ value of 34 nM for WT HIV-1. HIV-1 inhibitor-32 can be used for researching AIDS .

HY-142468

HIV-1 inhibitor-12	HIV	Infection
HIV-1 inhibitor-12 is potent *HIV-1* inhibitor. HIV-1 inhibitor-12 inhibits HIV-1 capsid protein polymerization with an IC₅₀ of 9 nM (WO2021104413A1, compound 1-1a) .

HY-152560

HIV-1 inhibitor-55	HIV	Infection
HIV-1 inhibitor-55 (compound 4d) inhibits WT HIV-1 with an EC₅₀ value of 8.6 nM. HIV-1 inhibitor-55 also shows inhibitory potency against single and double HIV-1 mutants. HIV-1 inhibitor-55 can be used for the research of virus infection .

HY-146088

HIV-1 inhibitor-31

HIV Infection

HIV-1 inhibitor-31 (compound 4) is a potent HIV-1 inhibitor. HIV-1 inhibitor-31 can be used for researching AIDS .

HIV-1 inhibitor-31	HIV	Infection
HIV-1 inhibitor-31 (compound 4) is a potent *HIV-1* inhibitor. HIV-1 inhibitor-31 can be used for researching AIDS .

HY-149991

HIV-1 inhibitor-56	HIV	Infection
HIV-1 inhibitor-56 (compound 12126065) is a potent HIV-1 non-nucleoside reverse transcriptase inhibitor. HIV-1 inhibitor-56 has antiviral activity against wild-type HIV-1 in TZM cells with an EC₅₀ value of 0.24 nM. HIV-1 inhibitor-56 penetrates the blood-brain barrier .

HY-142253

HIV-1 inhibitor-10

HIV Infection

HIV-1 inhibitor-10 is a nanomolar HIV-1 maturation inhibitor.

HIV-1 inhibitor-10	HIV	Infection
HIV-1 inhibitor-10 is a nanomolar *HIV-1* maturation inhibitor.

HY-150697

HIV-1 inhibitor-44	HIV	Others
HIV-1 inhibitor-44 (compound 11l) is a HIV-1 reverse transcriptase inhibitor. HIV-1 inhibitor-44 shows inhibitory activity against wild-type HIV-1 strain with an EC₅₀ value of 0.209 μM .

HY-152200

HIV-1 inhibitor-53	HIV Protease Reverse Transcriptase	Infection Inflammation/Immunology
HIV-1 inhibitor-53 is a *dual HIV-1 protease and reverse transcriptase* inhibitor. HIV-1 inhibitor-53 inhibits HIV-1 protease (PR) and reverse transcriptase (RT) activity with IC₅₀ values of 1.93 nM and 2.35 μM, respectively. HIV-1 inhibitor-53 can be used for the research of acquired immune deficiency syndrome (AIDS) .

HY-132291

HIV-1 inhibitor-8	HIV	Infection
HIV-1 inhibitor-8 is an orally active, low-toxicity and potent *HIV‑1* non-nucleoside reverse transcriptase inhibitor (NNRTI). HIV-1 inhibitor-8 yields exceptionally potent antiviral activities (EC₅₀=4.44~54.5 nM) against various *HIV‑1* strains. The IC₅₀ of HIV-1 inhibitor-8 against WT HIV-1 reverse transcriptase is 0.081 μM .

HY-146352

HIV-1 inhibitor-28	HIV	Infection Inflammation/Immunology
HIV-1 inhibitor-28 (compound 14j2) is a highly potent and selective *HIV-1* inhibitor with an EC₅₀ of 58 nM for WT HIV-1 strain and an IC₅₀ of 3.37 μM for HIV-1 WT reverse transcription (RT). HIV-1 inhibitor-28 exhibits relatively low cytotoxicity in MT-4 cells (CC₅₀ = 38.6 μM). HIV-1 inhibitor-28 can be used for researching AIDS .

HY-147723

HIV-1 inhibitor-39	HIV	Infection
HIV-1 inhibitor-39 (compound 3c) is a potent *HIV-1* inhibitor with an EC₅₀ of >112.88 µM. HIV-1 inhibitor-39 shows anti-RT (HIV-1 reverse transcriptase) activities with an IC₅₀ of 15.75 µM. HIV-1 inhibitor-39 shows cytotoxicity for MT-4 cells with an CC₅₀ of 112.9 µM .

HY-147553

HIV-1 inhibitor-36

HIV Infection

HIV-1 inhibitor-36 (Compound 2) is a potent HIV-1. HIV-1 inhibitor-36 has the potential for further development as novel latency reversing agents .
HY-147554

HIV-1 inhibitor-37

HIV Infection

HIV-1 inhibitor-37 (Compound 83) is a potent HIV-1. HIV-1 inhibitor-37 has the potential for further development as novel latency reversing agents .
HY-147555

HIV-1 inhibitor-38

HIV Infection

HIV-1 inhibitor-38 (Compound 91) is a potent HIV-1. HIV-1 inhibitor-38 has the potential for further development as novel latency reversing agents .

HIV-1 inhibitor-36	HIV	Infection
HIV-1 inhibitor-36 (Compound 2) is a potent *HIV-1. HIV-1 inhibitor*-36 has the potential for further development as novel latency reversing agents .

HIV-1 inhibitor-37	HIV	Infection
HIV-1 inhibitor-37 (Compound 83) is a potent *HIV-1. HIV-1 inhibitor*-37 has the potential for further development as novel latency reversing agents .

HIV-1 inhibitor-38	HIV	Infection
HIV-1 inhibitor-38 (Compound 91) is a potent *HIV-1. HIV-1 inhibitor*-38 has the potential for further development as novel latency reversing agents .

HY-146091

HIV-1 inhibitor-34	HIV	Infection
HIV-1 inhibitor-34 (compound 5q) is a potent and selective *HIV-1* inhibitor with an EC₅₀ of 6.4 nM for HIV-1 and a CC₅₀ of 16 μM in MT-4 cells. HIV-1 inhibitor-34 can be used for researching AIDS .

HY-146090

HIV-1 inhibitor-33	HIV	Infection
HIV-1 inhibitor-33 (compound 5n) is a potent and selective *HIV-1* inhibitor with an EC₅₀ of 8.6 nM for HIV-1 and a CC₅₀ of 18 μM in MT-4 cells. HIV-1 inhibitor-33 can be used for researching AIDS .

HY-144112

HIV-1 inhibitor-13	HIV	Infection
HIV-1 inhibitor-13 (compound 16c) is a orally active and potent *HIV-1* non-nucleoside reverse transcriptase inhibitor (NNRTI), with IC₅₀ of 0.14 μM (HIV-1 RT). HIV-1 inhibitor-13 shows activity against a panel of *HIV-1* resistant strains, with EC₅₀ values of 2.85-18.0 nM .

HY-147552

HIV-1 inhibitor-35	HIV	Infection
HIV-1 inhibitor-35 (compound 74) is a potent *HIV-1* inhibitor with EC₅₀s of 80 nM and 70 nM for LTR and CMV in HEK293 cells, respectively. HIV-1 inhibitor-35 has inhibitory activity against liver cancer cell HepG2 with a CC₅₀ of 40 nM. HIV-1 inhibitor-35 can be used as HIV-1 latency reversing agent .

HY-147903

HIV-1 inhibitor-42	HIV	Infection
HIV-1 inhibitor-42 (compound 5b) is a potent *HIV-1* inhibitor, with an IC₅₀ of 0.06 μM. HIV-1 inhibitor-42 inhibits HIV-1 RT RNA-dependent DNA polymerase and DNA-dependent DNA polymerase, with IC₅₀ values of 0.518 and 0.072 μM .

HY-146308

HIV-1 inhibitor-26	HIV	Infection
HIV-1 inhibitor-26 (compound 9a) is a potent HIV-1 reverse transcriptase (RT) inhibitor with an IC₅₀ value of 1.4 μM. HIV-1 inhibitor-26 has low cytotoxicity with a CC₅₀ of 1486 μM in PBMCs. HIV-1 inhibitor-26 can be used for researching AIDS .

HY-134851

HIV-1 inhibitor-6	HIV	Infection
HIV-1 inhibitor-6 (compound 9), a diheteroarylamide-based compound, is a potent HIV-1 pre-mRNA alternative splicing inhibitor. HIV-1 inhibitor-6 blocks HIV replication. HIV-1 inhibitor-6 is active against wild-type HIV-1IIIB (subtype B, X4-tropic) and HIV-1 97USSN54 (subtype A, R5-tropic) with EC₅₀s of 0.6 μM and 0.9 μM, respectively. HIV-1 inhibitor-6 inhibits HIV strains resistant to agents targeting HIV reverse transcriptase, protease, integrase, and coreceptor CCR5 with EC₅₀s ranging from 0.9 to 1.5 μM .

HY-150759

HIV-1 inhibitor-45	HIV	Infection
HIV-1 inhibitor-45 (compound IA-6) is a potent HIV-1 RNase H inhibitor with an IC₅₀ value of 0.067 μM. HIV-1 inhibitor-45 shows an antiviral activity .

HY-144113

HIV-1 inhibitor-14	HIV	Infection
HIV-1 inhibitor-14 (compound 14b) is a highly potent and broad-spectrum *HIV-1* non-nucleoside reverse transcriptase (RT) inhibitor with an EC₅₀ of 0.14 μM for HIV-1 RT. HIV-1 inhibitor-14 has inhibitory activity against HIV-1 WT and resistant strains with EC₅₀s of 5.79 ~ 28.3 nM .

HY-163161

HIV-1 inhibitor-62

HIV Infection

HIV-1 inhibitor-62 (compound 6) is an HIV-1 inhibitor that can be used in antiviral research .

HIV-1 inhibitor-62	HIV	Infection
HIV-1 inhibitor-62 (compound 6) is an *HIV-1* inhibitor that can be used in antiviral research .

HY-146018

HIV-1 inhibitor-23	HIV	Infection
HIV-1 inhibitor-23 (compound 12a) is a highly potent *HIV-1* non-nucleoside reverse transcriptase inhibitor, with EC₅₀s of 24.9 nM and 10.4 nM for HIV-1 WT and HIV-1 K103N, respectively. HIV-1 inhibitor-23 has low cytotoxicity (CC₅₀ > 221 μM) and a favorable in vitro microsomal stability .

HY-151933

HIV-1 inhibitor-49	HIV Reverse Transcriptase	Infection
HIV-1 inhibitor-49 is an orally active *HIV-1* inhibitor, is a HEPT analog. HIV-1 inhibitor-49 possesses great pharmacokinetics profiles and potent non-nucleoside reverse transcriptase inhibitory activity (IC₅₀=30 nM). HIV-1 inhibitor-49 exerts potential safety without acute toxicity in mouse model .

HY-147370

HIV-1 inhibitor-46	HIV	Infection
HIV-1 inhibitor-46 (compound 13d) is a potent *HIV-1* non-nucleoside reverse transcriptase inhibitor with an EC₅₀ value of 1.425 μM. HIV-1 inhibitor-46 can be used for the research of AIDS .

HY-146339

HIV-1 inhibitor-27	HIV	Infection Inflammation/Immunology
HIV-1 inhibitor-27 (compound 5) is a potent *HIV-1* inhibitor with IC₅₀s of 16 μM, 0.5 μM and 0.39 μM for HIV-1 YU2, NL4-3 and 89.6 strain, respectively. HIV-1 inhibitor-27 has low cytotoxicity with a CC₅₀ of 128 μM in TZM-bl cells. HIV-1 inhibitor-27 can be used for researching AIDS .

HY-144715

HIV-1 inhibitor-17	HIV	Infection
HIV-1 inhibitor-18 (compound V-25i) is a potent *HIV-1* capsid inhibitor with an EC₅₀ value of 2.57 μM for HIV-1 NL4-3. HIV-1 inhibitor-18 has certain cytotoxicity (MT-4 cells CC₅₀ >8.55) .

HY-144714

HIV-1 inhibitor-18	HIV	Infection
HIV-1 inhibitor-18 (compound II-13c) is a potent *HIV-1* capsid inhibitor with an EC₅₀ value of 5.14 μM for HIV-1 NL4-3. HIV-1 inhibitor-18 has certain cytotoxicity (MT-4 cells CC₅₀ >9.51) .

HY-149866

HIV-1 inhibitor-58	Cytochrome P450 HIV Reverse Transcriptase	Infection
HIV-1 inhibitor-58 (Compound 10c) is a broad-spectrum antiviral agent. HIV-1 inhibitor-58 is a non-nucleoside reverse transcriptase inhibitor. HIV-1 inhibitor-58 inhibits WT strain IIIB, NNRTI-resistant strains (such as K103N and E138K) in MT-4 cells, with EC₅₀ less than 50 nM. HIV-1 inhibitor-58 also inhibits CYP2C9 and CYP2C19 (IC₅₀: 2.06 μM, 1.91 μM). HIV-1 inhibitor-58 can be used for HIV infection reserch .

HY-144123

HIV-1 inhibitor-16	HIV	Infection
HIV-1 inhibitor-16 (compound 7a) is a highly potent *HIV-1* inhibitor with an EC₅₀ value of 1.3 nM for HIV-1 WT. HIV-1 inhibitor-16 also has certain inhibitory activity against HIV-1 K103N, E138K, Y181C and L100I strains with EC₅₀s of 5.4 nM, 9.2 nM, 22 nM and 35 nM. HIV-1 inhibitor-16 has favorable solubility and liver microsome stability, and does not exhibit apparent CYP enzymatic inhibitory activity or acute toxicity .

HY-147841

HIV-1 inhibitor-41	HIV Reverse Transcriptase	Infection
HIV-1 inhibitor-41 (Compound B23) is an orally active non-nucleoside HIV-1 reverse transcriptase inhibitor with EC₅₀ values of 20.8 nM and 50 nM against HIV-1 WT and mutant E138K strain, respectively. HIV-1 inhibitor-41 shows low hERG, no apparent CYP enzymatic inhibition and no acute toxicity .

HY-155114

HIV-1 inhibitor-59	HIV	Infection
HIV-1 inhibitor-59 (Compound I-5b) is a *HIV-1* inhibitor, with EC₅₀s of 5.62-171 nM against the wild-type (WT) and mutant HIV-1 strains. HIV-1 inhibitor-59 has moderate RT enzyme inhibitory activity (IC₅₀: 0.094-12.0 μM) .

HY-146353

HIV-1 inhibitor-29	HIV	Infection Inflammation/Immunology
HIV-1 inhibitor-29 (compound 14d2) is a potent *HIV-1* inhibitor with an EC₅₀ of 2.18 μM for HIV-1 IIIB. HIV-1 inhibitor-29 has high anti-resistance profile toward F227L/V106A strain (EC₅₀ = 0.974 μM), and exhibits low cytotoxicity in MT-4 cells (CC₅₀ = 211 μM). HIV-1 inhibitor-29 can be used for researching AIDS .

HY-144122

HIV-1 inhibitor-15	HIV	Infection
HIV-1 inhibitor-15 (compound 9d) is a highly potent and broad-spectrum *HIV-1* inhibitor. HIV-1 inhibitor-15 has inhibitory activity against HIV-1 WT, L100I, K103N, Y181C, E138K with EC₅₀s of 1.7 nM, 4 nM, 2 nM, 6 nM and 9 nM, respectively. HIV-1 inhibitor-15 has good solubility, safety profiles and favorable oral bioavailability .

HY-146017

HIV-1 inhibitor-22	HIV	Infection
HIV-1 inhibitor-22 (compound 11a) is a potent *HIV-1* non-nucleoside reverse transcriptase (RT) inhibitor, with an IC₅₀ value of 3.63 μM for HIV-1 RT. HIV-1 inhibitor-22 has antiretroviral activity against HIV-1 WT and K103N strains with EC₅₀s of 0.304 μM and 0.201 μM, also has low cytotoxicity (CC₅₀ > 227 μM)

HY-146019

HIV-1 inhibitor-24	HIV	Infection
HIV-1 inhibitor-24 (compound S-12a) is a highly potent HIV-1 reverse transcriptase, with an IC₅₀ value of 9.5 nM. HIV-1 inhibitor-24 has high antiretroviral activity against WT HIV-1 with an EC₅₀ of 1.6 nM, and exhibits relatively low cytotoxicity with a CC₅₀ of 9.07 μM in MT-4 cells. HIV-1 inhibitor-24 is well tolerated at a dose of 2 g/kg in mice and has a significant cardiovascular safety .

HY-147807

HIV-1 inhibitor-40	HIV Cytochrome P450	Infection
HIV-1 inhibitor-40 (Compound 4ab) is a non-nucleoside reverse transcriptase inhibitor (NNRTI) of *HIV-1* with an EC₅₀ of 1.9 nM. HIV-1 inhibitor-40 displays weak CYP sensitivity with IC₅₀ values of 5.16 μM and 4.51 μM against CYP2C9 and CYP2C19, respectively. HIV-1 inhibitor-40 has no apparent in vivo acute toxicity .

HY-128722

HIV-1 inhibitor-3

HIV Infection

HIV-1 inhibitor-3 is a HIV infection inhibitor extracted from patent US2018360927 .
HY-108255

HIV-1 inhibitor-60

HIV Infection

HIV-1 inhibitor-60 (compound 45) is an HIV inhibitor with the potential for the research of infection diseases .

HIV-1 inhibitor-3	HIV	Infection
HIV-1 inhibitor-3 is a *HIV* infection inhibitor extracted from patent US2018360927 .

HIV-1 inhibitor-60	HIV	Infection
HIV-1 inhibitor-60 (compound 45) is an *HIV* inhibitor with the potential for the research of infection diseases .

HY-146019A

HIV-1 inhibitor-25	HIV	Infection
HIV-1 inhibitor-25 (compound R-12a) is a highly potent HIV-1 reverse transcriptase, with an IC₅₀ value of 0.1061 μM. HIV-1 inhibitor-25 has high antiretroviral activity against WT HIV-1 with an EC₅₀ of 13.6 nM, and exhibits relatively low cytotoxicity with a CC₅₀ of 33.13 μM in MT-4 cells. HIV-1 inhibitor-25 also has inhibitory activity against HIV-1 mutant strains (L100I, K103N, Y181C, Y188L, E138K, F227L+V106A) with EC₅₀ of 0.1961 ~ 5.8136 μM. HIV-1 inhibitor-25 can be used for researching AIDS .

HY-146015

HIV-1 inhibitor-21	HIV	Infection
HIV-1 inhibitor-21 (compound 9b) is a potent *HIV-1* non-nucleoside reverse transcriptase (RT) inhibitor, with an IC₅₀ value of 0.55 μM for HIV-1 RT. HIV-1 inhibitor-21 has antiretroviral activity against HIV-1 WT and K103N strains with EC₅₀s of 12.7 nM and 10.4 nM, and has relatively low cytotoxicity (MT-4 cells CC₅₀ =10.2 μM) .

HY-150599

HIV-1 inhibitor-43	HIV DNA/RNA Synthesis	Infection
HIV-1 inhibitor-43 is a potent *HIV-1* inhibitor with an EC₅₀ of 21.3 nM, 6.2 nM, < 0.7 nM and < 0.7 nM for Y188L, K103N-Y181C, K103N and Y181C, respectively. HIV-1 inhibitor-43 can reduce HIV-1 RNA and protein p24 expression .

HY-142467

HIV-1 inhibitor-11

HIV Infection

HIV-1 inhibitor-11, a fused pyridine ring derivative, is a HIV-1 inhibitor. WO2021104413A1 ( compound 1-1b) .
HY-146753

HIV-1 inhibitor-20

HIV Infection

HIV-1 inhibitor-20 is a potent HIV-1 inhibitor by non-classical isosteric replacement of amide to 1,2,4-oxadiazoles .

Cat. No.	Product Name	Target	Research Area

HY-P4543

HIV-IN petide

HIV HIV Protease Infection

HIV-IN petide is a competitive inhibitor of HIV-1 protease (K_i=50 nM) .

HY-P4292

H-Gly-Pro-Gly-NH2	HIV Amino Acid Derivatives	Infection
H-Gly-Pro-Gly-NH2 is a tripeptide that inhibits *HIV-1* replication. H-Gly-Pro-Gly-NH2 inhibits the activity of HIV-1 III_B and HIV-2 ROD with EC₅₀ values of 35 µM and 30 µM, respectively. H-Gly Pro Gly NH2 inhibits HIV-1 replication in vitro by interfering with capsid formation. H-Gly Pro Gly NH2 has antiviral activity and can be used for virus research .

HY-151250

HIV-1 protease-IN-7

HIV Protease Infection

HIV-1 protease-IN-7 (compound 16) is an orally active HIV-1 protease inhibitor (IC₅₀=3.52 nM, EC₅₀=37 nM) .

HY-P2054

Mvt-101	HIV Protease	Infection
Mvt-101 is a hexapeptide-based inhibitor of HIV-1 protease. Mvt-101 is also reduced-peptide-bond inhibitor. Mvt-101 inhibits reproduction of the HIV virus by blocking protease action .

HY-120880

SKF107457

HIV Protease Infection

SKF107457 is an HIV-1 protease inhibitor that can be used in AIDS research .

HY-107760A

Decanoyl-RVKR-CMK TFA 1 Publications Verification DecRVKRcmk TFA	HIV	Infection Inflammation/Immunology
Decanoyl-RVKR-CMK (DecRVKRcmk) TFA inhibits over-expressed gp160 processing and HIV-1 replication .

HY-P1436

Acetyl-pepstatin

HIV Infection

Acetyl-pepstatin is a potent classical inhibitor of aspartic proteases (PRs) with XMRV PR and HIV-1 PR K_i values of 712 nM and 13 nM .

HY-P5497

C34 peptide	HIV	Others
C34 peptide is a biological active peptide. (This C34 peptide, also known as HR2, belongs to the helical region of gp41 of HIV, C-terminal heptad repeat 2 (HR2) defined as C helix or C peptide. It is known that HIV-1 enters cells by membrane fusion, C34 gp41 peptide is a potent inhibitors of HIV-1 fusion.)

HY-P2200

Siamycin I BMY-29304	HIV Antibiotic	Infection Inflammation/Immunology
Siamycin I (BMY-29304), a 21-residue tricyclic peptide, is a secondary metabolite in actinomycetes. Siamycin I is a *HIV* fusion inhibitor with ED₅₀s of 0.05 to 5.7 μM for acute HIV type 1 (HIV-1) and HIV-2 infections. Siamycin I inhibits the gelatinase and gelatinase biosynthesis-activating pheromone (GBAP) signaling via the FsrC-FsrA two-component regulatory system in a noncompetitive manner. Siamycin I suppresses the expression of both fsrBDC and gelE-sprE transcripts. Siamycin I, a lasso peptide, interacts with lipid II and inhibits cell wall biosynthesis. Siamycin I, an antibiotic, has the potential for enterococcal infections research .

HY-P35433

Tifuvirtide T-1249	HIV	Inflammation/Immunology
Tifuvirtide (T-1249) is a peptide human immunodeficiency virus type-1 (HIV-1) fusion inhibitor. Tifuvirtide is a synthetically designed hybrid retroviral envelope polypeptide. Tifuvirtide has antiretroviral activity. Tifuvirtide can be used for the research of HIV infection .

HY-P1065

Apelin-36(rat, mouse)	Apelin Receptor (APJ) HIV	Infection Cardiovascular Disease Metabolic Disease
Apelin-36(rat, mouse) is an endogenous orphan G protein-coupled receptor APJ agonist. Apelin-36(rat, mouse) binds to APJ receptors with an IC₅₀ of 5.4 nM, and potently inhibits cAMP production with an EC₅₀ of 0.52 nM. Apelin-36(rat, mouse) blocks entry of some *HIV-1* and *HIV-2* strains into NP-2/CD4 cells expressing APJ .

HY-P1066

Apelin-17(human, bovine)	Apelin Receptor (APJ) HIV	Infection
Apelin-17(human, bovine) is an endogenous orphan G protein-coupled receptor APJ agonist. Apelin-17(human, bovine) binds to human APJ receptors expressed in HEK 293 cells (pIC₅₀=9.02). Apelin-17(human, bovine) inhibits the entry of some *HIV-1* and *HIV-2* into the NP2/CD4 cells expressing APJ .

HY-P5738

Palicourein	Bacterial	Infection
Palicourein is a 37 amino acid cyclic polypeptide. Palicourein inhibits the in vitro cytopathic effects of HIV-1RF infection of CEM-SS cells with an EC₅₀ value of 0.1 μM and an IC₅₀ value of 1.5 μM .

HY-P0052A

Enfuvirtide acetate

2 Publications Verification

T20 acetate; DP178 acetate
HIV Infection

Enfuvirtide (T20; DP178) acetate is an anti-HIV-1 fusion inhibitor peptide.

HY-P1066A

Apelin-17(human, bovine) TFA	HIV Apelin Receptor (APJ)	Infection
Apelin-17(human, bovine) TFA is an endogenous orphan G protein-coupled receptor APJ agonist. Apelin-17(human, bovine) TFA binds to human APJ receptors expressed in HEK 293 cells (pIC₅₀=9.02). Apelin-17(human, bovine) TFA inhibits the entry of some *HIV-1* and *HIV-2* into the NP2/CD4 cells expressing APJ .

HY-P1065A

Apelin-36(rat, mouse) TFA	HIV Apelin Receptor (APJ)	Infection Cardiovascular Disease Metabolic Disease
Apelin-36(rat, mouse) TFA is an endogenous orphan G protein-coupled receptor APJ agonist. Apelin-36(rat, mouse) TFA binds to APJ receptors with an IC₅₀ of 5.4 nM, and potently inhibits cAMP production with an EC₅₀ of 0.52 nM. Apelin-36(rat, mouse) TFA blocks entry of some *HIV-1* and *HIV-2* strains into NP-2/CD4 cells expressing APJ .

HY-P4810

Polyphemusin II-Derived Peptide T140	CXCR	Infection
Polyphemusin II-Derived Peptide (T140), a CXCR4 inhibitor, shows high inhibitory activity against HIV-1 entry and the inhibitory effect on the binding of an anti-CXCR4 monoclonal antibody (12G5) to CXCR4 .

HY-P1753

VIR-165	HIV	Infection
VIR-165 is a modified form of virus inhibitory peptide (VIRIP) that binds the fusion peptide of the gp41 subunit and prevents its insertion into the target membrane. VIRIP inhibits a wide variety of human immunodeficiency virus type 1 (HIV-1) strains .

HY-P0052

Enfuvirtide

2 Publications Verification

T20; DP178
HIV Infection

Enfuvirtide (T20;DP178) is an anti-HIV-1 fusion inhibitor peptide.

HY-P7061

ALX 40-4C	CXCR Apelin Receptor (APJ)	Infection Endocrinology
ALX 40-4C is a small peptide inhibitor of the chemokine receptor CXCR4, inhibits SDF-1 from binding CXCR4 with a K_i of 1 μM, and suppresses the replication of X4 strains of HIV-1; ALX 40-4C Trifluoroacetate also acts as an antagonist of the APJ receptor, with an IC₅₀ of 2.9 μM.

HY-P7061A

ALX 40-4C Trifluoroacetate 1 Publications Verification	Apelin Receptor (APJ) CXCR	Infection Endocrinology
ALX 40-4C Trifluoroacetate is a small peptide inhibitor of the chemokine receptor CXCR4, inhibits SDF-1 from binding CXCR4 with a K_i of 1 μM, and suppresses the replication of X4 strains of HIV-1; ALX 40-4C Trifluoroacetate also acts as an antagonist of the APJ receptor, with an IC₅₀ of 2.9 μM.

HY-P1064

Apelin-36(human)	Apelin Receptor (APJ) HIV	Infection Cardiovascular Disease Metabolic Disease
Apelin-36(human) is an endogenous orphan G protein-coupled receptor APJ agonist, with an EC₅₀ of 20 nM. Apelin-36(human) shows high affinity to human APJ receptors expressed in HEK 293 cells (pIC₅₀=8.61). Apelin-36 has been linked to two major types of biological activities: cardiovascular and metabolic. Apelin-36(human) inhibits the entry of some *HIV-1* and *HIV-2* into the NP2/CD4 cells expressing APJ .

HY-P1034

DAPTA 1 Publications Verification D-Ala-peptide T-amide; Adaptavir	CCR HIV	Infection Endocrinology
DAPTA is a synthetic peptide, functions as a viral entry inhibitor by targeting selectively CCR5, and shows potent anti-HIV activities.

HY-P3554

Carbomethoxycarbonyl-D-Pro-D-Phe-OBzl	HIV	Infection
Carbomethoxycarbonyl-D-Pro-D-Phe-OBzl (compound (CPF(LL)) is an *HIV-1* inhibitor. Carbomethoxycarbonyl-D-Pro-D-Phe-OBzl interacts with gp120 to block gp120 binding to CD4 and preserve CD4-dependent T cell function .

HY-P1064A

Apelin-36(human) TFA	HIV Apelin Receptor (APJ)	Infection Cardiovascular Disease Metabolic Disease
Apelin-36(human) TFA is an endogenous orphan G protein-coupled receptor APJ agonist, with an EC₅₀ of 20 nM. Apelin-36(human) TFA shows high affinity to human APJ receptors expressed in HEK 293 cells (pIC5₅₀=8.61). Apelin-36(human) TFA has been linked to two major types of biological activities: cardiovascular and metabolic. Apelin-36(human) TFA inhibits the entry of some *HIV-1* and *HIV-2* into the NP2/CD4 cells expressing APJ .

HY-P10074

TAT-MEK1	ERK	Inflammation/Immunology
TAT-MEK1 is an inhibitor ofERK2, consisting of TAT and MEK1 (N-terminal), TAT (YGRKKRRQRRR) derived from human immunodeficiency (HIV-1) transcriptional trans activator (TAT), is a cell-penetrating peptide. TAT-MEK1 IC₅₀ in vitro for ERK2 is 29 μM .

HY-W714002

Feglymycin	HIV Bacterial	Infection
Feglymycin is a *HIV* replication inhibitor. Feglymycin is also an antibiotic peptide that has antibacterial activity (MIC: 32-64 μg/mL for Staphylococcus aureus) .

HY-P1104A

FC131 TFA

CXCR HIV Infection

FC131 TFA is a CXCR4 antagonist, inhibits [ ¹²⁵I]-SDF-1 binding to CXCR4, with an IC₅₀ of 4.5 nM. Anti-HIV activity .
HY-P10076

TAT-JBD20

L-HIV-TAT(48–57)-PP-JBD20
JNK Metabolic Disease

TAT-JBD20 (L-HIV-TAT(48–57)-PP-JBD20) is a JNK peptide inhibitor. TAT-JBD20 can be used for research of diabetes .
HY-P1104

FC131

CXCR HIV Infection

FC131 is a potent CXCR4 antagonist. FC131 inhibits [ ¹²⁵I]-SDF-1 binding to CXCR4 with an IC₅₀ of 4.5 nM. FC131 has anti-HIV activity .

HY-P0018

Pepstatin Maximum Cited Publications 26 Publications Verification Pepstatin A	HIV Protease Autophagy	Infection Inflammation/Immunology
Pepstatin (Pepstatin A) is a specific, orally active aspartic protease inhibitor produced by actinomycetes, with IC₅₀s of 4.5 nM, 6.2 nM, 150 nM, 290 nM, 520 nM and 260 nM for hemoglobin-pepsin, hemoglobin-proctase, casein-pepsin, casein-proctase, casein-acid protease and hemoglobin-acid protease, respectively. Pepstatin also inhibits HIV protease .

HY-P0018A

Pepstatin Trifluoroacetate Maximum Cited Publications 26 Publications Verification Pepstatin A Trifluoroacetate	HIV Protease Autophagy	Infection Inflammation/Immunology
Pepstatin (Pepstatin A) Trifluoroacetate is a specific, orally active aspartic protease inhibitor produced by actinomycetes, with IC₅₀s of 4.5 nM, 6.2 nM, 150 nM, 290 nM, 520 nM and 260 nM for hemoglobin-pepsin, hemoglobin-proctase, casein-pepsin, casein-proctase, casein-acid protease and hemoglobin-acid protease, respectively. Pepstatin Trifluoroacetate also inhibits HIV protease .

HY-P0018C

Pepstatin acetate Pepstatin A acetate	HIV Protease Autophagy	Infection Inflammation/Immunology
Pepstatin (Pepstatin A) acetate is a specific, orally active aspartic protease inhibitor produced by actinomycetes, with IC₅₀s of 4.5 nM, 6.2 nM, 150 nM, 290 nM, 520 nM and 260 nM for hemoglobin-pepsin, hemoglobin-proctase, casein-pepsin, casein-proctase, casein-acid protease and hemoglobin-acid protease, respectively. Pepstatin acetate also inhibits HIV protease .

HY-P0018B

Pepstatin Ammonium Maximum Cited Publications 26 Publications Verification Pepstatin A Ammonium	HIV Protease Autophagy	Infection Inflammation/Immunology
Pepstatin (Pepstatin A) Ammonium is a specific, orally active aspartic protease inhibitor produced by actinomycetes, with IC₅₀s of 4.5 nM, 6.2 nM, 150 nM, 290 nM, 520 nM and 260 nM for hemoglobin-pepsin, hemoglobin-proctase, casein-pepsin, casein-proctase, casein-acid protease and hemoglobin-acid protease, respectively. Pepstatin Ammonium also inhibits HIV protease .

HY-P2251

T-peptide	HIV Microtubule/Tubulin	Infection Inflammation/Immunology Cancer
T-peptide, a Tuftsin analog, can be used for the research of human immunodeficiency virus (HIV) infection. T-peptide prevents cellular immunosuppression and improves survival rate in septic mice. T-peptide also can inhibit the growth of residual tumor cells after surgical resection .

HY-P5395

TAT-GluR23A Fusion Peptide	HIV	Others
TAT-GluR23A Fusion Peptide is a biological active peptide. (This is the GluR23A sequence, a control inactive peptide used as a mutant counterpart to glutamate receptor endocytosis inhibitor (GluR23Y), connected to an 11 amino acid cell permeable HIV Trans-Activator of Transcription (TAT) protein transduction domain (PTD). GluR23A is derived from GluR23Y amino acids 869 to 877, with Ala substituted for Tyr, and thus lacking essential phosphorylation sites.Control peptide of HY-P2259)

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-N0457A

L-Chicoric Acid 1 Publications Verification (-)-Chicoric acid; trans-Caffeoyltartaric acid	Structural Classification other families Classification of Application Fields Simple Phenylpropanols Source classification Phenols Polyphenols Phenylpropanoids Plants Disease Research Fields Cancer	HIV Integrase HIV Endogenous Metabolite
L-Chicoric Acid ((-)-Chicoric acid) is a dicaffeoyltartaric acid and a potent, selective and reversible HIV-1 integrase inhibitor with an IC₅₀ of ~100 nM. L-Chicoric Acid inhibits *HIV-1* replication in tissue culture .

HY-N8368

Neotripterifordin	Structural Classification Terpenoids Source classification Celastraceae Diterpenoids Plants Tripterygium wilfordii Hook. f.	HIV
Neotripterifordin is a inhibitor of *HIV. Neotripterifordin has anti-HIV* replication activity in H9 lymphocyte cells with an EC₅₀ of 25 nM .

HY-N12082

HIV-IN-8	Structural Classification Source classification Phenols Polyphenols Plants Boraginaceae Arnebia euchroma (Royle) Johnst.	HIV
HIV-IN-8 (Compound 9) is a *HIV* inhibitor. HIV-IN-8 inhibits HIV replication with an EC₅₀ of 13 μg/mL .

HY-N10430

Patentiflorin A	Infection Classification of Application Fields Acanthaceae Justicia gendarussa N. L. Burman Source classification Lignans Phenylpropanoids Plants Disease Research Fields	HIV
Patentiflorin A is a potent, broadspectrum *HIV-1* inhibitor. Patentiflorin A also inhibits HIV drug-resistant strains .

HY-N11288

Methyl salvionolate A	Structural Classification Labiatae Source classification Phenols Polyphenols Salvia yunnanensis C. H. Wright Plants	HIV
Methyl salvionolate A is a potent inhibitor of *HIV-1. Methyl salvionolate A inhibits* P24 antigen in HIV-1 infected MT-4 cell with an EC₅₀ of 1.62 μg/ml. Methyl salvionolate A also inhibits HIV-1 reverse transcriptase, protease and integrase with IC₅₀s of 50.58, 10.73 and 7.58 μg/ml, respectively .

HY-N0365

Sennoside A 1 Publications Verification	Infection Quinones Structural Classification Classification of Application Fields Leguminosae Anthraquinones Source classification Folium Sennae Cassia angustifolia Vahl Cassia acutifolia Del. Plants Disease Research Fields	HIV
Sennoside A is an anthraquinone glycoside found in senna (Cassia angustifolia). Sennoside A is an *HIV-1* inhibitor (IC₅₀=3.8 μM) that inhibits HIV-1 replication. Sennoside A also inhibits HIV-1 reverse transcriptase (RT)-related DNA polymerase (RDDP) and ribonuclease H (Ribonuclease H) with IC₅₀s of 1.9 μM and 5.3 μM, respectively .

HY-N7330

Integracin B	Infection Microorganisms Classification of Application Fields Source classification Phenols Polyphenols Disease Research Fields	HIV Integrase HIV
Integracin B is a potent dimeric alkyl aromatic inhibitor of HIV-1 integrase discovered from the screening of fungal extracts using an in vitro assay. Integracin B inhibits both coupled and strand transfer activity of HIV-1 integrase .

HY-N12716

Longipedunin A	Structural Classification Source classification Lignans Phenylpropanoids Plants Kadsura longipedunculata Finet et Gagnep. Schisandraceae	HIV Protease
Longipedunin A is a HIV-1 Protease inhibitor with an IC₅₀ value of 50 µg/mL .

HY-10572

Efavirenz 5+ Cited Publications DMP 266; EFV; L-743726	Infection Structural Classification Natural Products Classification of Application Fields Source classification Endogenous metabolite Disease Research Fields Cancer	Reverse Transcriptase HIV Autophagy Endogenous Metabolite Parasite
Efavirenz (DMP 266) is a potent inhibitor of the wild-type HIV-1 reverse transcriptase with a K_i of 2.93 nM and exhibits an IC₉₅ of 1.5 nM for the inhibition of HIV-1 replicative spread in cell culture .

HY-B2224

Thiamine disulfide	Infection Structural Classification Natural Products Classification of Application Fields Source classification Metabolic Disease Endogenous metabolite Disease Research Fields	HIV Endogenous Metabolite
Thiamine disulfide, a vitamin B1 derivative, is an oxidized dimer of Thiamine. Thiamine disulfide is a potent *HIV-1* inhibitor. Thiamine disulfide significantly depresses HIV-1 transactivator (Tat) activity .

HY-N0365R

Sennoside A (Standard)	Infection Quinones Structural Classification Classification of Application Fields Source classification Plants Disease Research Fields	HIV
Sennoside A (Standard) is the analytical standard of Sennoside A. This product is intended for research and analytical applications. Sennoside A is an anthraquinone glycoside, found in Senna (Cassia angustifolia) . Sennoside A is a *HIV-1* inhibitor effective on HIV-1 replication .

HY-N2786

8-Prenylluteone	Structural Classification Flavonoids Erythrinasenegalensis DC. Leguminosae Source classification Plants Isoflavones	HIV Protease
8-Prenylluteone is a HIV-1 protease inhibitor, with an IC₅₀ of 4 μM .

HY-B0751

Fumagillin Amebacilin; NSC9168	Infection Microorganisms Classification of Application Fields Ketones, Aldehydes, Acids Source classification Disease Research Fields	Parasite HIV Antibiotic
Fumagillin(NSC9168) is an antimicrobial compound first isolated in 1949 from the fungus Aspergillus fumigatu. Fumagillin can inhibits *HIV‐1* infection through the inhibition of HIV-1 viral protein R (Vpr) activity.

HY-N4100

Trilobatin 1 Publications Verification	Structural Classification Classification of Application Fields Plants Dihydrochalcones Fagaceae Naphthalene Quinones Sweeteners Food Research Infection Quinones Flavonoids Lithocarpus polystachyus Disease Research Fields	HIV SGLT
Trilobatin, a natural sweetener derived from Lithocarpus polystachyus Rehd , Trilobatin is an *HIV-1* entry inhibitor targeting the HIV-1 Gp41 envelope . Neuroprotective effects . Trilobatin is also a SGLT1/2 inhibitor that selectively induces the proliferation of human hepatoblastoma cells .

HY-N6849

InteriotherinA	Classification of Application Fields Source classification Lignans Metabolic Disease Phenylpropanoids Plants Schisandraceae Disease Research Fields Schisandra chinensis (Turcz.) Baill.	HIV
Interiotherin A is a lignan with a dibenzocyclooctadiene skeleton isolated from Kadsura interior. Interiotherin A inhibits *HIV* replication to exhibit anti-HIV activity, it has a role as a metabolite and an anti-HIV agent .

HY-N0751

Scutellarin 5+ Cited Publications	Infection Structural Classification Flavonoids Scutellaria baicalensis Georgi Classification of Application Fields Flavones Labiatae Source classification Phenols Polyphenols Plants Disease Research Fields	STAT Akt HIV
Scutellarin, an active flavone isolated from Scutellaria baicalensis, can down-regulates the STAT3/Girdin/Akt signaling in HCC cells, and inhibits RANKL-mediated MAPK and NF-κB signaling pathway in osteoclasts. Scutellarin is active against *HIV-1IIIB, HIV-1(74V)* and *HIV-1KM018* with EC₅₀s of 26 μM, 253 μM and 136 μM, respectively.

HY-10572R

Efavirenz (Standard) DMP 266 (Standard); EFV (Standard); L-743726 (Standard)	Structural Classification Natural Products Source classification Endogenous metabolite	Reverse Transcriptase HIV Autophagy Endogenous Metabolite Parasite
Efavirenz (Standard) is the analytical standard of Efavirenz. This product is intended for research and analytical applications. Efavirenz (DMP 266) is a potent inhibitor of the wild-type HIV-1 reverse transcriptase with a K_i of 2.93 nM and exhibits an IC₉₅ of 1.5 nM for the inhibition of HIV-1 replicative spread in cell culture .

HY-N3222

Myriceric acid B	Rhoiptelea chiliantha Diels et Hand.-Mazz. Triterpenes Structural Classification Juglandaceae Terpenoids Source classification Plants	HIV
Myriceric acid B is a potent *HIV-1* entry inhibitor targeting gp41. Myriceric acid B is an antitumor agent .

HY-10571

Delavirdine U 90152; BHAP-U 90152	Infection Classification of Application Fields Disease Research Fields	HIV Reverse Transcriptase
Delavirdine (U 90152) is a potent, highly specific and orally active non-nucleoside reverse transcriptase inhibitor (NNRTI). Delavirdine selectively inhibits HIV-1 reverse transcriptase (RT) (IC₅₀=0.26 μM) over DNA polymerase α (IC₅₀=440 μM) and polymerase δ (IC₅₀>550 μM). Delavirdine is an inhibitor of HIV-1 replication and can can be used for the study of AIDs .

HY-137242

Ingenol-3-palmitate	Structural Classification Terpenoids Source classification Diterpenoids Euphorbiaceae Plants Euphorbia kansuensis Prokh.	HIV
Ingenol-3-palmitate, an ingenane diterpenoid, is a nature product that could be isolated from the roots of Euphorbia ebracteolata. Ingenol-3-palmitate is a potent *HIV-1* (HIV) inhibitor with an IC₅₀ value of 4.1 nM .

HY-113074

Glycolithocholic acid 3-sulfate Glycolithocholate sulfate; Sulfolithocholylglycine; SLCG	Triterpenes Structural Classification Terpenoids Source classification Endogenous metabolite	HIV Endogenous Metabolite
Glycolithocholic acid 3-sulfate (SLCG) is a cholic acid derivative and a metabolite of glycolithocholic acid. Glycolithocholic acid 3-sulfate inhibits replication of *HIV-1* in vitro. Glycolithocholic acid 3-sulfate can be used for the research of HIV infection and gallbladder disease .

HY-142074

Inophyllum B (+)-Inophyllum B	Structural Classification Source classification Rosaceae Coumarins Phenylpropanoids Plants Photinia serratifolia (Desf.) Kalkman	Reverse Transcriptase HIV
Inophyllum B ((+)-Inophyllum B) is a potent *HIV* Reverse Transcriptase inhibitor with an IC₅₀ value of 38 nM. Inophyllum B inhibits *HIV-1* (IC₅₀=1.4 μM) in vitro cell culture. Inophyllum B can be isolated from the acetone extract of the giant African snail, Achatina fulica .

HY-127078

Salaspermic acid	Triterpenes Structural Classification Salacia macrosperma Wight Terpenoids Source classification Celastraceae Plants	HIV
Salaspermic acid is a new triterpene acid isolated from Salacia macrosperma Wight. Salaspermic acid is an inhibitor of HIV reverse transcriptase and HIV replication in H9 lymphocyte cells .

HY-N1372A

Fangchinoline 4 Publications Verification	Infection Stephania tetrandra S. Moore Alkaloids Monophenols Classification of Application Fields Source classification Phenols Plants Isoquinoline Alkaloids Disease Research Fields Menispermaceae	HIV FAK Apoptosis Autophagy
Fangchinoline is isolated from Stephania tetrandra with extensive biological activities, such as enhancing immunity, anti-inflammatory sterilization and anti-atherosclerosis. Fangchinoline, a novel *HIV-1* inhibitor, inhibits HIV-1 replication by impairing gp160 proteolytic processing . Fangchinoline targets Focal adhesion kinase (FAK) and suppresses FAK-mediated signaling pathway in tumor cells which highly expressed FAK . Fangchinoline induces apoptosis and adaptive autophagy in bladder cancer .

HY-N2571

Corydine	Infection Alkaloids Monophenols other families Classification of Application Fields Source classification Phenols Plants Isoquinoline Alkaloids Disease Research Fields	Reverse Transcriptase HIV
Corydine is a naturally occurring alkaloid which can be extracted from plants such as Croton echinocarpus leaves. Corydine is efficient on inhibiting reverse transcriptase (RT) activity with an IC₅₀ of 356.8 μg/mL. Corydine displays significant in vitro anti-HIV potential, inhibiting 40% of the HIV-1 reverse transcriptase enzyme activity at a concentration of 450 μg/mL of Corydine .

HY-N1487

Oleanonic acid 3-Oxooleanolic acid	Triterpenes Structural Classification other families Classification of Application Fields Terpenoids Source classification Plants Disease Research Fields Cancer	HIV
Oleanonic acid (3-Oxooleanolic acid) is a triterpenoid, inhibits infection by HIV.

HY-N9340

Hypoglaunine D	Infection Alkaloids Classification of Application Fields Source classification Celastraceae Pyridine Alkaloids Plants Disease Research Fields Tripterygium hypoglaucum (Levl. ) Hutch.	HIV
Hypoglaunine D is an analogue of Triptonine B and acts as an *anti-HIV* compound. Hypoglaunine D inhibits HIV* replication* in H9 lymphocytes with an EC₅₀ value of 22 μg/ml .

HY-N6773

Cytochalasin A	Infection Alkaloids Microorganisms Pyrrole Alkaloids Classification of Application Fields Source classification Disease Research Fields	HIV Protease Fungal
Cytochalasin A is a cell-permeable fungal toxin that is an oxidized derivative of cytochalasin B. Cytochalasin A is an inhibitor of HIV-1 protease (IC₅₀=3 μM) and inhibits actin polymerization and interferes with microtubule assembly by reacting with sulfhydryl groups. Antibiotic and fungicidal activitives .

HY-17411

Limonin 5+ Cited Publications Limonoic acid 3,19:16,17 dilactone	Triterpenes Structural Classification Classification of Application Fields Terpenoids Source classification Rutaceae Plants Endogenous metabolite Disease Research Fields Citrus reticulata Blanco Cancer	HIV Apoptosis Endogenous Metabolite Cytochrome P450 P-glycoprotein
Limonin inhibits *HIV-1* with an EC₅₀ of 60.0 μM. Limonin induces human colon adenocarcinoma cells apoptosis with an IC₅₀ of 54.74 μM. Limonin has antiviral and antitumor activities .

HY-N0842

Bevirimat 1 Publications Verification PA-457; MPC-4326; YK FH312	Infection Triterpenes Structural Classification Classification of Application Fields Terpenoids Source classification Myrtaceae Plants Disease Research Fields Syzygium aromaticum	HIV
Bevirimat (PA-457; MPC-4326; YK FH312) is an anti-HIV agent derived from a betulinic acid-like compound; is believed to inhibit HIV by a novel mechanism, so-called maturation inhibition.

HY-W009783

1-Deoxymannojirimycin hydrochloride	Infection Alkaloids Piperidine Alkaloids other families Classification of Application Fields Source classification Plants Disease Research Fields	HIV Influenza Virus
1-Deoxymannojirimycin hydrochloride is a selective class I α1,2-mannosidase inhibitor with an IC₅₀ of 20 μM. 1-Deoxymannojirimycin hydrochloride is also a N-linked glycosylation inhibitor and inhibits *HIV‐1* strains. 1-Deoxymannojirimycin hydrochloride has antiviral activity .

HY-122935

Nigranoic acid	Infection Triterpenes Classification of Application Fields Terpenoids Source classification Plants Schisandraceae Disease Research Fields Schisandra chinensis (Turcz.) Baill.	HIV Reverse Transcriptase
Nigranoic acid is a triterpenoid separated from Schisandra chinensis. Nigranoic acid inhibits HIV-1 reverse transcriptase. Nigranoic acid exhibits protective effects on brain through PARP/AIF signaling pathway in cerebral ischemia-reperfusion animal model .

HY-116700

Hinnuliquinone	Structural Classification Natural Products Nepenthes mirabilis (Lour.) Druce Source classification Plants Nepenthaceae	HIV Protease HIV
Hinnuliquinone is a C2-symmetric dimeric non-peptide fungal metabolite inhibitor of HIV-1 protease. Hinnuliquinone is a bis-indolyl-2,5-dihydroxybenzoquinone pigment, that can be isolated from Nodulisphorium hinnuleum .

HY-17367

Atazanavir 10+ Cited Publications BMS-232632	Infection Structural Classification Alkaloids Classification of Application Fields Source classification Pyridine Alkaloids Endogenous metabolite Disease Research Fields Cancer	HIV HIV Protease SARS-CoV Cytochrome P450 P-glycoprotein Endogenous Metabolite
Atazanavir (BMS-232632), a highly selective HIV-1 protease inhibitor, is the first protease inhibitor approved for once-daily administration . Atazanavir (BMS-232632) is a substrate and inhibitor of CYP3A4, and an inhibitor and inducer of P-glycoprotein (P-gp) . Atazanavir is also a SARS-CoV 3CL ^pro inhibitor with an IC₅₀ of 3.49 μM .

HY-17367A

Atazanavir sulfate 10+ Cited Publications BMS-232632 sulfate	Infection Structural Classification Alkaloids Classification of Application Fields Source classification Pyridine Alkaloids Endogenous metabolite Disease Research Fields Cancer	HIV HIV Protease SARS-CoV Cytochrome P450 P-glycoprotein Endogenous Metabolite
Atazanavir (BMS-232632) sulfate, a highly selective HIV-1 protease inhibitor, is the first protease inhibitor approved for once-daily administration . Atazanavir sulfate is a substrate and inhibitor of CYP3A4, and an inhibitor and inducer of P-glycoprotein (P-gp) . Atazanavir sulfate is also a SARS-CoV 3CL ^pro inhibitor with an IC₅₀ of 3.49 μM .

HY-N6795

Leptomycin A	Infection Structural Classification Microorganisms Classification of Application Fields Antibiotics Source classification Antibacterial Disease Research Disease Research Fields Other Antibiotics	CRM1 HIV Antibiotic
Leptomycin A, a Streptomyces metabolite, is an inhibitor of CRM1 (exportin 1) that blocks CRM1 interaction with nuclear export signals, preventing the nuclear export of a broad range of proteins. Leptomycin A suppresses HIV-1 replication. Less potent than Leptomycin B .

HY-137309

4-Deoxy-4α-phorbol	Structural Classification Terpenoids Source classification Euphorbia cooperi N. E. Br. ex A. Berger Diterpenoids Euphorbiaceae Plants	HIV
4-Deoxy-4α-phorbol is a tetracyclic diterpene found in E. desmondi. It has been used in the semisynthesis of inhibitors of the HIV-1-induced cytopathic effect on MT-4 cells and 4α-phorbol esters .

HY-N11097

FK-3000	Structural Classification Alkaloids Piperidine Alkaloids Source classification Plants Stephania delavayi Diels Menispermaceae	Apoptosis HSV HIV
FK-3000 is a potent anti-tumor agent that inhibits the growth of carcinoma cells through apoptosis and induction cell cycle arrest. FK-3000 also exhibit antiviral effects against HSV-1 and *HIV-1* .

HY-N2532

Diphyllin	Structural Classification Classification of Application Fields Source classification Lignans Dysosma versipellis (Hance) M. Cheng ex Ying Plants Infection Monophenols Phenols Phenylpropanoids Berberidaceae Inflammation/Immunology Disease Research Fields	VSV HIV Proton Pump Influenza Virus
Diphyllin is an arylnaphthalene lignan isolated from Justicia procumbens and is a potent *HIV-1* inhibitor with an IC50 of 0.38 μM. Diphyllin is active against vesicular stomatitis virus (VSV) and influenza virus . Diphyllin is a vacuolar type H ⁺-ATPase (V-ATPase) inhibitor with an IC₅₀ value of 17 nM and inhibits lysosomal acidification in human osteoclasts . Diphyllin inhibits NO production with an IC₅₀ of 50 μM and has anticancer and anti-inflammatory activities .

HY-17427

Emtricitabine 4 Publications Verification BW1592	Infection Structural Classification Natural Products Classification of Application Fields Source classification Endogenous metabolite Disease Research Fields	HIV Reverse Transcriptase Endogenous Metabolite
Emtricitabine is a nucleoside reverse transcriptase inhibitor (NRTI) with an EC₅₀ of 0.01 μM in PBMC cell. It is an antiviral agent for the treatment of *HIV* infection.

HY-17431

Fosamprenavir Calcium Salt 4 Publications Verification GW433908G	Infection Structural Classification Natural Products Classification of Application Fields Source classification Endogenous metabolite Disease Research Fields	HIV Endogenous Metabolite
Fosamprenavir Calcium Salt (GW433908G) is a phosphate ester proagent of the antiretroviral protease inhibitor Amprenavir, with improved solubility . Anti-HIV infection .

HY-78726

Fosamprenavir 4 Publications Verification Amprenavir phosphate; GW 433908	Infection Structural Classification Natural Products Classification of Application Fields Source classification Endogenous metabolite Disease Research Fields	HIV Endogenous Metabolite
Fosamprenavir (Amprenavir phosphate;GW 433908) is a phosphate ester proagent of the antiretroviral protease inhibitor Amprenavir, with improved solubility . Anti-HIV infection .

HY-N0554

Escin IA	Infection Triterpenes other families Classification of Application Fields Terpenoids Hippocastanaceae Source classification Aesculus hippocastanum Plants Disease Research Fields Cancer	HIV Protease
Escin IA is a triterpene saponin isolated from Aesculus hippocastanum, which inhibits HIV-1 protease with IC₅₀ values of 35 μM. Escin IA has anti-TNBC metastasis activity, and its action mechanisms involved inhibition of epithelial-mesenchymal transition process by down-regulating LOXL2 expression .

HY-122920

Soyasaponin II	Triterpenes Structural Classification Classification of Application Fields Leguminosae Terpenoids Source classification Plants Inflammation/Immunology Disease Research Fields Glycine soja Sieb. Et Zucc.	HSV CMV Influenza Virus HIV NOD-like Receptor (NLR) YB-1
Soyasaponin II is a saponin with antiviral activity. Soyasaponin II inhibits the replication of HSV-1, HCMV, influenza virus, and HIV-1. Soyasaponin II shows potent inhibition on HSV-1 replication. Soyasaponin II serves as a inhibitor for YB-1 phosphorylation and NLRP3 inflammasome priming and could protect mice against LPS/GalN induced acute liver failure .

HY-124786

Juniferdin	Isodon serra (Maximowicz) Kudo Structural Classification Terpenoids Sesquiterpenes Source classification Plants Umbelliferae	HIV
Juniferdin is an inhibitor of Protein disulfide isomerase (PDI) (IC₅₀=3.5 μM), aiming to block *HIV* transmission. Juniferdin is cytotoxic, and also inhibits platelet aggregation .

HY-N3511

Triptonine B	Infection Classification of Application Fields Terpenoids Sesquiterpenes Source classification Celastraceae Plants Tripterygium wilfordii Hook. f. Disease Research Fields	HIV
Triptonine B, a sesquiterpene pyridine alkaloid, inhibits *HIV* replication in H9 lymphocytes with an EC₅₀ value of <0.10 μg/mL .

HY-N3506

Wilfortrine	Infection Alkaloids Classification of Application Fields Source classification Celastraceae Pyridine Alkaloids Plants Tripterygium wilfordii Hook. f. Disease Research Fields Inflammation/Immunology	HIV
Wilfortrine is a bioactive sesquiterpene alkaloid. Wilfortrine exhibits immunosuppresive effects. Wilfortrine also can inhibit leukaemia cell growth in mice and shows anti-HIV activity .

HY-111321

Fuscin	Quinones Structural Classification Microorganisms Classification of Application Fields Source classification Metabolic Disease Naphthalene Quinones Disease Research Fields	Oxidative Phosphorylation CCR HIV Bacterial Mitochondrial Metabolism Endogenous Metabolite
Fuscin, a fungal metabolite, CCR5 receptor antagonist with anti-HIV effects. Fuscin is a respiration and oxidative phosphorylation inhibitor, and also a mitochondrial SH-dependent transport-linked functions inhibitor .

HY-N10076

Ganomycin I	Structural Classification Microorganisms Source classification Phenols Polyphenols	HMG-CoA Reductase (HMGCR) Glucosidase HIV Protease
Ganomycin I is a dual inhibitor of α-Glucosidase and HMG-CoA reductase. Ganomycin I can also inhibits HIV protease. Ganomycin I exhibits anti-diabetic and anti-osteoclastogenesis effects .

HY-B0439

Sulfadoxine Sulphadoxine	Infection Structural Classification Natural Products Classification of Application Fields Source classification Endogenous metabolite Disease Research Fields	Parasite HIV Antibiotic Endogenous Metabolite
Sulfadoxine(Sulphadoxine) is a long acting sulfonamide that is used, usually in combination with other agents, for respiratory, urinary tract and malarial infections. Sulfadoxine inhibits *HIV* replication in peripheral blood mononuclear cells.

Cat. No.	Product Name	Chemical Structure

HY-10570S

Nevirapine-d4
Nevirapine-d₄ is deuterium labeled Nevirapine. Nevirapine is a non-nucleoside inhibitor of HIV-1 reverse transcriptase used to treat and prevent HIV/AIDS; with a Ki of 270 μM[1].

HY-13238S1

Dolutegravir-d3

Dolutegravir-d₃ is the deuterium labeled Dolutegravir. Dolutegravir (S/GSK1349572) is a highly potent and orally bioavailable HIV integrase strand transfer inhibitor with an IC50 of 2.7 nM for HIV-1 integrase-catalyzed strand transfer. Dolutegravir (S/GSK1349572) inhibits HIV-1 viral replication with an IC50 of 0.51 nM in peripheral blood mononuclear cells. Dolutegravir retains a high potency against the HIV-1 Y143R, N155H, and G140S/Q148H mutants (EC50=3.6-5.8 nM)[1][2].

HY-14740S

Elvitegravir-d8
Elvitegravir-d₈ is deuterium labeled Elvitegravir. Elvitegravir (GS-9137; JTK-303; D06677) is an HIV integrase inhibitor for HIV-1IIIB, HIV-2EHO and HIV-2ROD with IC50 of 0.7 nM, 2.8 nM and 1.4 nM, respectively.

HY-10572S1

Efavirenz-13C6
Efavirenz- ¹³C₆ is the ¹³C-labeled Efavirenz. Efavirenz (DMP 266) is a potent inhibitor of the wild-type HIV-1 reverse transcriptase with a Ki of 2.93 nM and exhibits an IC95 of 1.5 nM for the inhibition of HIV-1 replicative spread in cell culture[1].

HY-13238S2

Dolutegravir-d5

Dolutegravir-d₅ is deuterium labeled Dolutegravir. Dolutegravir (S/GSK1349572) is a highly potent and orally bioavailable HIV integrase strand transfer inhibitor with an IC50 of 2.7 nM for HIV-1 integrase-catalyzed strand transfer. Dolutegravir (S/GSK1349572) inhibits HIV-1 viral replication with an IC50 of 0.51 nM in peripheral blood mononuclear cells. Dolutegravir retains a high potency against the HIV-1 Y143R, N155H, and G140S/Q148H mutants (EC50=3.6-5.8 nM)[1][2].

HY-17367S

Atazanavir-d15

Atazanavir-d15 is the d₁₅ labled Atazanavir (HY-17367). Atazanavir is a selective HIV-1 protease inhibitor .
HY-17367S1

Atazanavir-d18

Atazanavir-d18 is the d₁₈ labled Atazanavir (HY-17367). Atazanavir is a selective HIV-1 protease inhibitor .

HY-14588S1

Lopinavir-d8
Lopinavir-d₈ (ABT-378-d8) is the deuterium labeled Lopinavir. Lopinavir (ABT-378) is a highly potent, selective peptidomimetic inhibitor of the HIV-1 protease, with Kis of 1.3 to 3.6 pM for wild-type and mutant HIV protease. Lopinavir acts by arresting maturation of HIV-1 thereby blocking its infectivity[1][2]. Lopinavir is also a SARS-CoV 3CLpro inhibitor with an IC50 of 14.2 μM[3].

HY-B0116S

Stavudine-d4
Stavudine-d₄ is the deuterium labeled Stavudine. Stavudine (d4T) is an orally active nucleoside reverse transcriptase inhibitor (NRTI). Stavudine has activity against HIV-1 and HIV-2. Stavudine also inhibits the replication of mitochondrial DNA (mtDNA). Stavudine reduces NLRP3 inflammasome activation and modulates Amyloid-β autophagy. Stavudine induces apoptosis[1][2][3][4].

HY-10570S1

Nevirapine-d3
Nevirapine-d₃ (BI-RG 587-d3) is the deuterium labeled Nevirapine. Nevirapine is a non-nucleoside inhibitor of HIV-1 reverse transcriptase used to treat and prevent HIV/AIDS; with a Ki of 270 μM[1].

HY-14588S

(rel)-Lopinavir-d8

(rel)-Lopinavir-d₈ ((rel)-ABT-378-d₈)is the deuterium labeledLopinavir(HY-14588) . Lopinavir (ABT-378) is a highly potent, selective peptidomimetic inhibitor of the HIV-1 protease, with K_is of 1.3 to 3.6 pM for wild-type and mutant HIV protease. Lopinavir acts by arresting maturation of HIV-1 thereby blocking its infectivity . Lopinavir is also a SARS-CoV 3CL ^pro inhibitor with an IC₅₀ of 14.2 μM .

HY-10046S

Plerixafor-d4
Plerixafor-d₄ is the deuterium labeled Plerixafor. Plerixafor (AMD 3100) is a selective CXCR4 antagonist with an IC50 of 44 nM. Plerixafor, an immunostimulant and a hematopoietic stem cell (HSC) mobilizer, is an allosteric agonist of CXCR7. Plerixafor inhibits HIV-1 and HIV-2 replication with an EC50 of 1-10 nM[1][2][3][4][7].

HY-132508S

Etravirine-d8

Etravirine-d₈ is the deuterium labeled Etravirine. Etravirine (R165335) is a non-nucleoside reverse transcriptase inhibitor (NNRTI) used for the treatment of HIV[1][2].

HY-N0285S

Imperatorin-d6
Imperatorin-d6 (Ammidin-d6) is the deuterium labeled Imperatorin. Imperatorin is a BChE inhibitor and HIV-1 replication inhibitor. Imperatorin shows mild activity against Gram-negative bacteria .

HY-W751039

Bictegravir-d4

Bictegravir-d4 is a deuterium of Bictegravir (HY-17605). Bictegravir (GS-9883) is a potent inhibitor of HIV-1 integrase with an IC₅₀ of 7.5 nM .

HY-15287S

Nelfinavir-d3
Nelfinavir-d₃ (AG1341-d3) is the deuterium labeled Nelfinavir. Nelfinavir (AG-1341) is a potent and orally bioavailable HIV-1 protease inhibitor (Ki=2 nM) for HIV infection. Nelfinavir is a broad-spectrum, anticancer agent[1][2][3].

HY-90001S

Ritonavir-d6
Ritonavir-d₆ is the deuterium labeled Ritonavir. Ritonavir (ABT 538) is an inhibitor of HIV protease used to treat HIV infection and AIDS. Ritonavir is also a SARS-CoV 3CLpro inhibitor with an IC50 of 1.61 μM[1][2].

HY-90001S1

Ritonavir-13C,d3
Ritonavir- ¹³C,d₃ is the ¹³C- and deuterium labeled Ritonavir. Ritonavir (ABT 538) is an inhibitor of HIV protease used to treat HIV infection and AIDS. Ritonavir is also a SARS-CoV 3CLpro inhibitor with an IC50 of 1.61 μM.

HY-17430S1

Amprenavir-d4-1
Amprenavir-d₄-1 is deuterium labeled Amprenavir. Amprenavir (VX-478) is a HIV protease inhibitor (Ki=0.6 nM) used to treat HIV infection. Amprenavir is also a SARS-CoV 3CLpro inhibitor with an IC50 of 1.09 μM.

HY-B1422S

9-Aminoacridine-13C6

9-Aminoacridine-13C6 is the ¹³C-labeled 9-Aminoacridine(HY-B1422). 9-Aminoacridine, a fluorescent probe, acts as an indicator of pH for quantitative determination of transmembrane pH gradients (inside acidic). 9-Aminoacridine is an antimicrobial. 9-Aminoacridine exerts its antimicrobial activity by interacting with specific bacterial DNA and disrupting the proton motive force in K. pneumoniae. 9-Aminoacridine is a HIV-1 inhibitor and inhibits HIV LTR transcription highly dependent on the presence and location of the amino moiety. 9-Aminoacridine inhibits virus replication in HIV-1 infected cell lines. 9-Aminoacridine is used as a Rifampin (RIF; HY-B0272) adjuvant for the multidrug-resistant K. pneumoniae infections .

HY-10572BS

(Rac)-Efavirenz-d4

(Rac)-Efavirenz-d₄ is a labelled racemic Efavirenz. Efavirenz (DMP 266) is a potent inhibitor of the wild-type HIV-1 reverse transcriptase with a Ki of 2.93 nM and exhibits an IC95 of 1.5 nM for the inhibition of HIV-1 replicative spread in cell culture[1]. (Rac)-Efavirenz-d4 is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

HY-17430S

Amprenavir-d4
Amprenavir-d₄ is the deuterium labeled Amprenavir. Amprenavir (VX-478) is a HIV protease inhibitor (Ki=0.6 nM) used to treat HIV infection. Amprenavir is also a SARS-CoV 3CLpro inhibitor with an IC50 of 1.09 μM[1][2].

HY-10572S

Efavirenz-d5

Efavirenz-d₅ (DMP 266-d5) is the deuterium labeled Efavirenz. Efavirenz (DMP 266) is a potent inhibitor of the wild-type HIV-1 reverse transcriptase with a Ki of 2.93 nM and exhibits an IC95 of 1.5 nM for the inhibition of HIV-1 replicative spread in cell culture[1]. Efavirenz-d5 is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

HY-10224S

Panobinostat-d4

Panobinostat-d₄ is the deuterium labeled Panobinostat. Panobinostat (LBH589; NVP-LBH589) is a potent and orally active non-selective HDAC inhibitor, and has antineoplastic activities[1][2]. Panobinostat induces HIV-1 virus production even at low concentration range 8-31 nM, stimulates HIV-1 expression in latently infected cells[4]. Panobinostat induces cell apoptosis and autophagy. Panobinostat can be used for the study of refractory or relapsed multiple myeloma[3].

HY-10224S1

Panobinostat-d4 hydrochloride

Panobinostat-d₄ (hydrochloride) is deuterium labeled Panobinostat. Panobinostat (LBH589; NVP-LBH589) is a potent and orally active non-selective HDAC inhibitor, and has antineoplastic activities[1][2]. Panobinostat induces HIV-1 virus production even at low concentration range 8-31 nM, stimulates HIV-1 expression in latently infected cells[4]. Panobinostat induces cell apoptosis and autophagy. Panobinostat can be used for the study of refractory or relapsed multiple myeloma[3].

HY-10574S

Rilpivirine-d6
Rilpivirine-d₆ is the deuterium labeled Rilpivirine. Rilpivirine (R278474) is a potent and specific diarylpyrimidine (DAPY) non-nucleoside reverse transcriptase inhibitor (NNRTI). Rilpivirine has high antiviral activity against wild-type HIV (EC50=0.4 nM) and mutant viruses (EC50=0.1-2.0 nM). Rilpivirine has a high genetic barrier to resistance development of HIV[1][2].

HY-10353S

Raltegravir-d4

Raltegravir-d₄ is deuterium labeled Raltegravir. Raltegravir is a potent integrase (IN) inhibitor, used to treat HIV infection.

HY-90001S3

rel-Ritonavir-d6
rel-Ritonavir-d₆ (rel-ABT 538-d₆; rel-RTV-d₆) is the deuterium labeled Ritonavir (HY-90001). Ritonavir (ABT 538) is an inhibitor of HIV protease used to treat HIV infection and AIDS. Ritonavir is also a SARS-CoV 3CLpro inhibitor with an IC₅₀ of 1.61 μM .

HY-17367S3

Atazanavir-d5

Atazanavir-d₅ is the deuterium labeled Atazanavir. Atazanavir (BMS-232632), a highly selective HIV-1 protease inhibitor, is the first protease inhibitor approved for once-daily administration[1]. Atazanavir (BMS-232632) is a substrate and inhibitor of CYP3A4, and an inhibitor and inducer of P-glycoprotein (P-gp)[2]. Atazanavir is also a SARS-CoV 3CLpro inhibitor with an IC50 of 3.49 μM[3].

HY-17367S2

Atazanavir-d9

Atazanavir-d₉ is the deuterium labeled Atazanavir. Atazanavir (BMS-232632), a highly selective HIV-1 protease inhibitor, is the first protease inhibitor approved for once-daily administration[1]. Atazanavir (BMS-232632) is a substrate and inhibitor of CYP3A4, and an inhibitor and inducer of P-glycoprotein (P-gp)[2]. Atazanavir is also a SARS-CoV 3CLpro inhibitor with an IC50 of 3.49 μM[3].

HY-17367S4

Atazanavir-d6

Atazanavir-d₆ is deuterium labeled Atazanavir. Atazanavir (BMS-232632), a highly selective HIV-1 protease inhibitor, is the first protease inhibitor approved for once-daily administration[1]. Atazanavir (BMS-232632) is a substrate and inhibitor of CYP3A4, and an inhibitor and inducer of P-glycoprotein (P-gp)[2]. Atazanavir is also a SARS-CoV 3CLpro inhibitor with an IC50 of 3.49 μM[3].

HY-17605S

Bictegravir-15N,d2
Bictegravir- ¹⁵N,d₂ (GS-9883- ¹⁵N,d₂) is the ¹⁵N and deuterium labeled Bictegravir (HY-17605) . Bictegravir (GS-9883) is a potent inhibitor of HIV-1 integrase with an IC₅₀ of 7.5 nM .

HY-90005S

Etravirine D4

Etravirine-d₄ is the deuterium labeled Etravirine. Etravirine is a non-nucleoside reverse transcriptase inhibitor (NNRTI) used for the treatment of HIV.

HY-14266S

Dapivirine-d11
Dapivirine-d₁₁ is the deuterium labeled Dapivirine. Dapivirine (TMC120), the prototype of diarylpyrimidines (DAPY), is an orally active and nonnucleoside reverse transcriptase inhibitor (NRTI). Dapivirine (TMC120) binds directly to HIV-1 reverse transcriptase. Dapivirine (TMC120) regulates autophagy and induced Akt, Bad and SAPK/JNK activations[1][2].

HY-10353AS

Raltegravir-d3 potassium
Raltegravir-d₃ (potassium) is the deuterium labeled Raltegravir potassium. Raltegravir (MK 0518) potassium is a potent integrase (IN) inhibitor, used to treat HIV infection[1][2].

HY-90006S

5-Fluorouracil-d1
5-Fluorouracil-d is the deuterium labeled 5-Fluorouracil. 5-Fluorouracil (5-FU) is an analogue of uracil and a potent antitumor agent. 5-Fluorouracil affects pyrimidine synthesis by inhibiting thymidylate synthetase thus depleting intracellular dTTP pools. 5-Fluorouracil induces apoptosis and can be used as a chemical sensitizer[1][2]. 5-Fluorouracil also inhibits HIV[3].

HY-90006S2

5-Fluorouracil-15N2
5-Fluorouracil- ¹⁵N₂ is the ¹⁵N-labeled 5-Fluorouracil. 5-Fluorouracil (5-FU) is an analogue of uracil and a potent antitumor agent. 5-Fluorouracil affects pyrimidine synthesis by inhibiting thymidylate synthetase thus depleting intracellular dTTP pools. 5-Fluorouracil induces apoptosis and can be used as a chemical sensitizer[1][2]. 5-Fluorouracil also inhibits HIV[3].

HY-113904S

(Rac)-Tenofovir-d6

(Rac)-Tenofovir-d₆ is a labelled racemic Tenofovir. Tenofovir (GS 1278) is a nucleotide reverse transcriptase inhibitor to treat HIV and chronic Hepatitis B (HBV)[1].
HY-B0689S

Indinavir-d6

Indinavir-d₆ is the deuterium labeled Indinavir. Indinavir (MK-639; L735524) is a potent and specific HIV protease inhibitor that appears to have good oral bioavailability.

HY-90006S1

5-Fluorouracil-13C,15N2

5-Fluorouracil- ¹³C, ¹⁵N₂ is the ¹³C and ¹⁵N labeled 5-Fluorouracil[1]. 5-Fluorouracil (5-FU) is an analogue of uracil and a potent antitumor agent. 5-Fluorouracil affects pyrimidine synthesis by inhibiting thymidylate synthetase thus depleting intracellular dTTP pools. 5-Fluorouracil induces apoptosis and can be used as a chemical sensitizer[2][3]. 5-Fluorouracil also inhibits HIV[4].

HY-N0492S

α-Lipoic Acid-d5
α-Lipoic Acid-d₅ is the deuterium labeled α-Lipoic Acid. α-Lipoic Acid is an antioxidant, which is an essential cofactor of mitochondrial enzyme complexes. α-Lipoic Acid inhibits NF-κB-dependent HIV-1 LTR activation[1][2][3]. α-Lipoic Acid induces endoplasmic reticulum (ER) stress-mediated apoptosis in hepatoma cells[4].

HY-15592AS

Cabotegravir-d3 sodium
Cabotegravir-d₃ (sodium) is the deuterium labeled Cabotegravir sodium. Cabotegravir sodium is a highly potent HIV integrase inhibitor with an IC50 value of 2.5 nM for HIVADA. Cabotegravir sodium is primarily metabolized by uridine diphosphate glucuronosyltr

HY-15592S2

Cabotegravir-d3-1

Cabotegravir d3-1 (GSK-1265744-d3-1) is a deuterium substitute of Cabotegravir. Cabotegravir is a potent HIV integrase inhibitor used in AIDS research

HY-90006S3

5-Fluorouracil-13C4,15N2

5-Fluorouracil- ¹³C₄, ¹⁵N₂ is the ¹³C and ¹⁵N labeled 5-Fluorouracil[1]. 5-Fluorouracil (5-FU) is an analogue of uracil and a potent antitumor agent. 5-Fluorouracil affects pyrimidine synthesis by inhibiting thymidylate synthetase thus depleting intracellular dTTP pools. 5-Fluorouracil induces apoptosis and can be used as a chemical sensitizer[2][3]. 5-Fluorouracil also inhibits HIV[4].

HY-17007S

Saquinavir-d9
Saquinavir-d₉ is the deuterium labeled Saquinavir. Saquinavir(Ro 31-8959) is an HIV Protease inhibitor used in antiretroviral therapy. Saquinavir is also a SARS-CoV 3CLpro inhibitor with an IC50 of 1.36 μM[1][2].

HY-78726S

Fosamprenavir-d4
Fosamprenavir-d₄ is deuterium labeled Fosamprenavir. Fosamprenavir (Amprenavir phosphate;GW 433908) is a phosphate ester proagent of the antiretroviral protease inhibitor Amprenavir, with improved solubility[1]. Anti-HIV infection[1].

HY-135330

Lamivudine-13C,15N2
Lamivudine- ¹³C, ¹⁵N₂ is a labelled impurity of Lamivudine (BCH-189). Lamivudine is a nucleoside reverse transcriptase inhibitors (NRTIs), and can inhibit HIV reverse transcriptase 1/2 and the reverse transcriptase of hepatitis B virus .

HY-B0439S

Sulfadoxine-d4
Sulfadoxine-d₄ is the deuterium labeled Sulfadoxine. Sulfadoxine(Sulphadoxine) is a long acting sulfonamide that is used, usually in combination with other agents, for respiratory, urinary tract and malarial infections. Sulfadoxine inhibits HIV replication in peripheral blood mononuclear cells.

HY-17427S

Emtricitabine-15N,d2
Emtricitabine- ¹⁵N,d₂ is a ¹⁵N-labeled and deuterium labeled Emtricitabine. Emtricitabine is a nucleoside reverse transcriptase inhibitor (NRTI) with an EC50 of 0.01 μM in PBMC cell. It is an antiviral agent for the treatment of HIV infection.

HY-17427S2

Emtricitabine-13C,15N2
Emtricitabine- ¹³C, ¹⁵N₂ (BW1592- ¹³C, ¹⁵N₂) is a ¹³C- and ¹⁵N-labeled Emtricitabine (HY-17427). Emtricitabine is a nucleoside reverse transcriptase inhibitor (NRTI) with an EC₅₀ of 0.01 μM in PBMC cell. It is an antiviral agent for the treatment of *HIV* infection.

Cat. No.	Product Name		Classification

HY-13025

**HIV-1 integrase inhibitor** 1 Publications Verification		Azide
HIV-1 integrase inhibitor is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. Strain-promoted alkyne-azide cycloaddition (SPAAC) can also occur with molecules containing DBCO or BCN groups.

HY-16776A

(2S,5S)-Censavudine (2S,5S)-Festinavir; (2S,5S)-BMS-986001; (2S,5S)-OBP-601		Alkynes
(2S,5S)-Censavudine ((2S,5S)-OBP-601) is the (2S,5S)-enantiomer of Censavudine. Censavudine, a nucleoside reverse transcriptase inhibitor, is a potent HIV inhibitor . (2S,5S)-Censavudine is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

HY-16776

Censavudine Festinavir; BMS-986001; OBP-601		Alkynes
Censavudine (OBP-601; BMS-986001), a nucleoside analog, is a nucleoside reverse transcriptase inhibitor. Censavudine is a potent *HIV* inhibitor with EC₅₀ ranges from 30 nM to 81 nM and 450 nM to 890 nM for *HIV-2* and *HIV-1*, respectively . Censavudine is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

HY-105268

AzddMeC CS-92		Azide
AzddMeC (CS-92) is an antiviral nucleoside analogue and a potent potent, selective and orally active HIV-1 reverse transcriptase and HIV-1 replication inhibitor. In *HIV-1*-infected human PBM cells and *HIV-1*-infected human macrophages, the EC₅₀ values of AzddMeC are 9 nM and 6 nM, respectively . AzddMeC is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. Strain-promoted alkyne-azide cycloaddition (SPAAC) can also occur with molecules containing DBCO or BCN groups.

HY-138561

EFdA-TP		Alkynes
EFdA-TP is a potent nucleoside reverse transcriptase (RT) inhibitor. EFdA-TP inhibits RT-catalyzed DNA synthesis as an effective immediate or delayed chain terminator (ICT or DCT). EFdA-TP inhibits *HIV-1* RT with multiple mechanisms .

HY-19314A

Azvudine hydrochloride RO-0622 hydrochloride; FNC hydrochloride		Azide
Azvudine (RO-0622) hydrochloride is a potent nucleoside reverse transcriptase inhibitor (NRTI), with antiviral activity on *HIV, HBV* and HCV. Azvudine hydrochloride exerts highly potent inhibition on HIV-1 (EC₅₀s ranging from 0.03 to 6.92 nM) and HIV-2 (EC₅₀s ranging from 0.018 to 0.025 nM). Azvudine hydrochloride inhibits NRTI-resistant viral strains . Azvudine (hydrochloride) is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. Strain-promoted alkyne-azide cycloaddition (SPAAC) can also occur with molecules containing DBCO or BCN groups.

HY-19314

Azvudine RO-0622; FNC		Azide
Azvudine (RO-0622) is a potent nucleoside reverse transcriptase inhibitor (NRTI), with antiviral activity on *HIV, HBV* and HCV. Azvudine exerts highly potent inhibition on HIV-1 (EC₅₀s ranging from 0.03 to 6.92 nM) and HIV-2 (EC₅₀s ranging from 0.018 to 0.025 nM). Azvudine inhibits NRTI-resistant viral strains . Azvudine is a click chemistry reagent, itcontains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. Strain-promoted alkyne-azide cycloaddition (SPAAC) can also occur with molecules containing DBCO or BCN groups.

HY-152233

Reverse transcriptase-IN-4		Azide
Reverse transcriptase-IN-4 (compound F10) is a potent and selective non-nucleoside reverse transcriptase (NNRT) inhibitor with an EC₅₀ value of 0.053 μM for wild-type HIV-1 and an EC₅₀ value of 0.26 μM for HIV-1 mutant E138K . Reverse transcriptase-IN-4 is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. Strain-promoted alkyne-azide cycloaddition (SPAAC) can also occur with molecules containing DBCO or BCN groups.

HY-138561A

EFdA-TP tetraammonium		Alkynes
EFdA-TP tetraammonium is a potent nucleoside reverse transcriptase (RT) inhibitor. EFdA-TP tetraammonium inhibits RT-catalyzed DNA synthesis as an effective immediate or delayed chain terminator (ICT or DCT). EFdA-TP tetraammonium inhibits *HIV-1* RT with multiple mechanisms . EFdA-TP (tetraammonium) is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

HY-138561B

EFdA-TP tetrasodium		Alkynes
EFdA-TP tetrasodium is a potent nucleoside reverse transcriptase (RT) inhibitor. EFdA-TP tetrasodium inhibits RT-catalyzed DNA synthesis as an effective immediate or delayed chain terminator (ICT or DCT). EFdA-TP tetrasodium inhibits *HIV-1* RT with multiple mechanisms . EFdA-TP (tetrasodium) is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

HY-120832

Azt-pmap		Azide
Azt-pmap, a nucleoside analogue, is an aryl phosphate derivative of AZT. Azt-pmap shows anti-HIV activity . AZT is a nucleoside reverse transcriptase inhibitor (NRTI) for HIV infection . Azt-pmap is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. Strain-promoted alkyne-azide cycloaddition (SPAAC) can also occur with molecules containing DBCO or BCN groups.

HY-125810

4'-Ethynyl-2'-deoxyadenosine		Alkynes
4'-Ethynyl-2'-deoxyadenosine (4'-E-dA), a nucleoside reverse transcriptase (RT) inhibitor, is an antiretroviral agent which is potent against drug-resistant HIV variants, with an EC₅₀ of 98 nM in MT-4 cells for anti-HIV-1 activity . 4'-Ethynyl-2'-deoxyadenosine is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

HY-148202

Influenza antiviral conjugate-1		Alkynes
Influenza antiviral conjugate-1 (INT-2) is a *HIV* inhibitor, shows potent cell fusion inhibition . Influenza antiviral conjugate-1 is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

HY-111640

3'-Azido-3'-deoxy-5-methylcytidine		Azide
3'-Azido-3'-deoxy-5-methylcytidine (CS-92) is a potent xenotropic murine leukemia-related retrovirus (XMRV) inhibitor with a CC₅₀ of 43.5 μM in MCF-7 cells. 3'-Azido-3'-deoxy-5-methylcytidine also inhibits HIV-1 reverse transcriptase with an EC₅₀ of 0.06 μM in peripheral blood mononuclear (PBM) cells . 3'-Azido-3'-deoxy-5-methylcytidine is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. Strain-promoted alkyne-azide cycloaddition (SPAAC) can also occur with molecules containing DBCO or BCN groups.

HY-148191

CL-197		Alkynes
CL-197 is an orally active and long-acting purine *anti-HIV* nucleoside reverse transcriptase** inhibitor (NRTI). CL-197 has potential effect on the research of viral, oncological and cerebrovascular diseases . CL-197 is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

HY-139262

FNC-TP		Azide
FNC-TP is the intracellular active form of FNC. FNC is a potent *nucleoside reverse transcriptase inhibitor* (NRTI), with antiviral activity on HIV, HBV and HCV** . FNC-TP is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. Strain-promoted alkyne-azide cycloaddition (SPAAC) can also occur with molecules containing DBCO or BCN groups.

HY-139262A

FNC-TP trisodium		Azide
FNC-TP trisodium is the intracellular active form of FNC. FNC is a potent *nucleoside reverse transcriptase inhibitor* (NRTI), with antiviral activity on HIV, HBV and HCV** . FNC-TP (trisodium) is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. Strain-promoted alkyne-azide cycloaddition (SPAAC) can also occur with molecules containing DBCO or BCN groups.

HY-17413S

Zidovudine-d3 Azidothymidine-d₃; AZT-d₃; ZDV-d₃		Azide
Zidovudine-d₃ is the deuterium labeled Zidovudine. Zidovudine is a nucleoside reverse transcriptase inhibitor (NRTI), widely used to treat HIV infection. Zidovudine increases CRISPR/Cas9-mediated editing frequency. Zidovudine-d3 is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. Strain-promoted alkyne-azide cycloaddition (SPAAC) can also occur with molecules containing DBCO or BCN groups.

HY-137522

Zidovudine O-β-D-glucuronide sodium 3'-Azido-3'-deoxythymidine β-D-glucuronide sodium		Azide
Zidovudine O-β-D-glucuronide (3'-Azido-3'-deoxythymidine β-D-glucuronide) sodium is the major metabolite of Zidovudine. Zidovudine is a nucleoside reverse transcriptase inhibitor (NRTI), widely used to treat HIV infection . Zidovudine O-β-D-glucuronide (sodium) is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. Strain-promoted alkyne-azide cycloaddition (SPAAC) can also occur with molecules containing DBCO or BCN groups.

HY-17413S1

Zidovudine-13C,d3 Azidothymidine-¹³C,d₃; AZT-¹³C,d₃; ZDV-¹³C,d₃		Azide
Zidovudine- ¹³C,d₃ is the ¹³C- and deuterium labeled Zidovudine. Zidovudine is a nucleoside reverse transcriptase inhibitor (NRTI), widely used to treat HIV infection. Zidovudine increases CRISPR/Cas9-mediated editing frequency. Zidovudine-13C,d3 is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. Strain-promoted alkyne-azide cycloaddition (SPAAC) can also occur with molecules containing DBCO or BCN groups.

HY-106850

3′-Azido-2′,3′-dideoxyuridine AzdU; AzddU; CS-87		Azide
3′-Azido-2′,3′-dideoxyuridine (AzdU) is a nucleoside analog of Zidovudine (HY-17413). 3′-Azido-2′,3′-dideoxyuridine is a potent inhibitor of human immunodeficiency virus (HIV) replication in human peripheral blood mononuclear cells (PBMC) with limited toxicity for human bone marrow cells (BMC) . 3′-Azido-2′,3′-dideoxyuridine is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. Strain-promoted alkyne-azide cycloaddition (SPAAC) can also occur with molecules containing DBCO or BCN groups.

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